The addition of gemtuzumab ozogamicin to induction chemotherapy in AML reduces relapse and improves survival in the majority of patients of all ages
Ponatinib and inhibition of the PI3K/Akt/mTOR pathway induces cell death and protective autophagy in TKI-resistant CML stem/progenitor cells
Identification of the key survival pathways underlying CML stem cell resistance to TKIs
Identification of novel therapeutic targets to eliminate chronic myeloid leukaemia stem cells
A comprehensive diagnostic approach improves the diagnostic accuracy of invasive fungal disease (IFD) in adult haemato-oncology patients undergoing HSCT or high dose chemotherapy - results of the King's Prospective Aspergillosis Study (NCT00816088)
BK virus-associated haemorrhagic cystitis is associated with GVHD and significant morbidity post haematopoietic stem cell transplant
Favorable outcomes in elderly and high-risk patients with AML and MDS following T-cell depleted reduced intensity conditioned allogeneic stem cell transplantation
Continued absence of transfusion-associated graft versus host disease despite failures to provide irradiated products to patients at risk - more than a decade of data from SHOT
Is presence of ETV6/RUNX1 an independent prognostic marker for relapse risk? Retrospective analysis of ETV6/RUNX1-positive patients treated on MRCUKALL2003, at Birmingham Children's Hospital, UK
Performing immunophenotyping by flow cytometry on bone marrow trephines from paediatric patients
Potentially modifiable risk factors associated with neurocognitive deficits in adolescents with sickle cell disease and normal brain MRI
Elevated Trib2 with Notch1 activation in pediatric/ adult T-ALL
Th1 and Th2 cytokine levels are increased in murine models of human sickle cell anaemia maintained on a high protein calories feed
Transposon driven leukaemogenesis follows an accelerated Darwinian-like evolution in a mouse model of Npm1c+ acute myeloid leukaemia
Rs10974944 germline polymorphism, JAK2 V617F somatic mutation, haematological parameters, and morbidity in 49,488 individuals from the general population
Adoptive therapy with redirected MHC class I-restricted antigen-specific regulatory T cells is a potential novel cellular therapy for graft-versus-host disease
A predictive phenolog approach identifies that And1 and Sec13 are required to maintain genome stability
Thrombocytopenia with Absent Radii (TAR) syndrome is cause by compound inheritance of low-frequency regulatory SNPs and a rare null mutation in exon-junction complex subunit RBM8A
Nine predicted unpaired cysteine residues in von Willebrand factor are essential for VWF secretion
XAMOS
Novel MHC-peptide-T cell receptor interfaces are necessary for inhibitor formation in mild/moderate haemophilia A secondary to missense mutation genotypes
The mechanisms underlying the positive inotropic effect of activated protein C
Presenting D-dimer and early symptom severity are independent predictors of post thrombotic syndrome following a first deep vein thrombosis
Clinical and laboratory characteristics of 31 subjects with heritable dysfibrinogenaemia
Warfarin dose prediction in children using pharmacogenetics information
The addition of rituximab to fludarabine and cyclophosphamide (FC) improves overall survival in newly diagnosed mantle cell lymphoma (MCL)
Mutations in SF3B1, but not NOTCH1, are independently associated with survival in the UK CLL4 trial
Minimal residual disease is highly predictive of outcome in myeloma
The significance of deletion architecture, ATM mutational status and genomic complexity in 11q deleted CLL
First analysis of a phase II multicentre trial of rituximab, gemcitabine, cyclophosphamide, vincristine and prednisolone (R-GCVP) for patients with newly diagnosed diffuse large B cell lymphoma (DLBCL) considered unsuitable for anthracycline containing chemo-immunotherapy. An NCRI lymphoma clinical studies group trial. CRUK/07/007
Chronic lymphocytic leukaemia lymph node T-cells show evidence of chronic antigenic stimulation and a skewed T-cell receptor repertoire
Efficacy and safety of conventional-dose lenalidomide followed by low-dose maintenance lenalidomide for relapsed/refractory mantle cell lymphoma (MCL)
The CDK inhibitor CR8 diminishes NFκB signalling in CLL cells
Alpha thalassaemia and the severity of Plasmodium falciparum infection in microcytic children from the Ashanti region of Ghana
Hypermethylation of 28S ribosomal RNA in β-thalassemia
Implementation of nurse authorisation of blood components in NHS Scotland
Too much blood, too quickly
Evaluating the introduction of entonox for bone marrow aspirations
National comparative audit of red cell transfusion in medical patients
Patients with biochemical iron overload and low risk or negative HFE genotypes are a diagnostic and therapeutic challenge in clinical haematology
Detection of the BRAF V600E mutation in hairy cell leukaemia and other mature B-cell malignancies
Presence of mutations in the NOTCH1 signalling pathway has a beneficial impact on outcome in paediatric T-ALL patients treated on the MRC UKALL2003 trial
The development of humanized DARC FYB(ES) transgenic mouse
The impact of mutant level on clinical outcome in acute myeloid leukaemia differs according to the mutated gene
Germline activating JAK2-mutation in a family with hereditary thrombocytosis
Patients with haematological malignancy requiring intensive care treatment
Utility of blood cultures in febrile patients in a BCSH Level 4 Centre
Haematology readmission
Generic e-mail laboratory advice service to general practitioners provides prompt, effective and popular means of communication
An audit of the quality of consent forms for chemotherapy in a combined Haematology and Oncology Day Unit
The demographic profile of patients receiving regular cobalamin (B12) therapy in a local general practice surgery
Digital morphology
The last resort in pyrexia of unknown origin
Sysmex XN analysers - a novel modular blood cell counting system
Abstract Withdrawn
IFN stimulation can influence early stem cell fate decisions
Demand management in a district general hospital laboratory - lessons learned from audit of B12 and folate requests
Improving the immediate management of febrile neutropenia in a district general hospital
An update on development of a quality assurance programme for the reporting of bone marrow morphology in the North Trent Haemato-oncology Diagnostic Service
Do all medical patients need a routine coagulation sample on admission to a medical admissions unit? A prospective audit at a district general hospital
An investigation of the role of CXCL1-CXCR2 signalling in haemopoietic stem cell quiescence
Bordetella holmesii in asplenic patients
Production of a gallery for the WHO for morphological identification of haematopoietic cells, for use in developing nations
Use of intravenous iron for management of iron deficiency in a haematology day care setting
Haemoglobin measurement by blood gas analysers in acute hospital point of care settings
An outreach monoclonal gammopathy of undetermined significance monitoring system in a large district general hospital
Transition to an integrated reporting system for bone marrow biopsies from patients with suspected haematological malignancy - experience in North Central London/West Essex
Treating ‘haematophobia’ in medical students
Iron deficiency anaemia in pregnancy - is it a concern?
Can estimated GFR replace EDTA GFR for haematology patients receiving nephrotoxic chemotherapy agents?
Estimation of fetomaternal haemorrhage using Kleihauer test in the National Maternity Hospital
The value of computerised VTE assessments
Gammaplex® IVIg in subjects with chronic idiopathic (immune) thrombocytopenic purpura
VKORC1 and CYP2C9 genotype is associated with over-anticoagulation during initiation of warfarin therapy in children
Assessment of haemostasis in malaria and HIV infected subjects in Nnewi, South East
An audit of venousthromboembolism (VTE) risk assessments in the obstetric department at King's College Hospital (KCH)
Post-thrombotic syndrome is an independent determinant of quality of life following a first deep vein thrombosis
Two previously unreported mutations, Cys849Phe and Cys858Ser, identified in patients with type 2N VWD in five families from different regions of Iran
Problems in the use of prothrombin complex concentrate for reversal of anticoagulation in actual clinical practice
Outcomes from root cause analysis of hospital-associated thrombosis over twelve months
Prothrombin/phosphatidyl serine antibodies in patients with antiphospholipid antibodies
Significantly higher mortality associated with hospital acquired thrombosis compared with community acquired thrombosis
Review of heritable thrombophilia testing in Northern Ireland (NI)
Expanding the GAPP project - feasibility of remote platelet phenotyping
The management of patients admitted with suspected pulmonary embolus
Impaired primary haemostasis in severe sepsis despite elevated von Willebrand factor
Haemostasis point of care testing in theatres and cardiac catheter laboratories
The changing portfolio of UK NEQAS for Blood Coagulation
Usefulness of Q scans in diagnostic algorithm of pulmonary embolism
An audit of hospital-acquired venous thromboembolism (HAT) rates according to medical specialty at the Great Western Hospital Swindon
Cardiac procedure and surgery in haemophiliacs - a case series from a single haemophilia centre
Assessing risk for venous thrombo-embolism (VTE) in early pregnancy
Abstract Withdrawn
Dental procedures in patients with bleeding disorders and the cost effectiveness of ‘make your own’ tranexamic acid mouthwash
Smaller fixed doses of prothrombin complex concentrate are effective for reversal of warfarin related over-anticoagulation and reduce costs significantly
A single-centre retrospective study of prothrombin complex concentrate (octaplex) use
Computerised patient records enhance communication, audit potential and patient safety in a large haemophilia comprehensive care centre
Single centre experience of reduced intensity rituximab in acquired haemophilia A
High incidence of venous thromboembolism in newly diagnosed lymphoma patients
The influence of ABO(H) blood group on the clotting potential of whole blood and plasma component therapy from healthy blood donors
Investigation of FXIII deficiency
Investigation of a prolonged APTT
Therapeutic dalteparin dosing in obese patients
Venous-thromboembolism in patients with plaster casts for lower leg fracture
Thrombophilia testing in the west of Scotland
Preventing venous thrombosis in patients admitted to a district general hospital for medical and surgical treatments
The NFIL3 transcription factor is preferentially expressed in BCR-independent mature B-cell malignancy
Toll-like receptor-1 triggering on multiple myeloma cells modulates their adhesion to bone marrow stromal cells
Targeting chronic lymphocytic leukaemia survival and proliferation with bioactive cell penetrating peptides
Characterising CD31-CD38 signalling in chronic lymphocytic leukaemia
An audit on the use of flow cytometry as a means to detect haematological malignancy in lymph node biopsies
A systematic investigation of the cell surface proteome of chronic lymphoytic leukaemia
c-MET is expressed in the nucleus of normal Tlymphocytes and is induced during progression through the cell cycle commitment point
An untimely reminder of an uncommon complication
High-dose methylprednisolone and rituximab treatment in refractory and cytopenic chronic lymphocytic leukaemia patients
Abnormal serum free light chain ratio predicts inferior overall survival in mantle cell lymphoma
Haemophagocytic lymphohistiocytosis following fludarabine /cyclophosphamide chemotherapy for chronic lymphocytic leukaemia
Interim analysis results of a phase II trial of single agent ofatumumab in the treatment of relapsed/refractory mantle cell lymphoma
First UK experience of BTK inhibitor PCI-32765 - dramatic responses in relapsed/refractory mantle cell lymphoma
Single centre experience of secondary CNS involvement in rituximab treated high IPI diffuse large B cell lymphoma
Reversibility of renal insufficiency secondary to myeloma - a single institution experience
Alemtuzumab based therapy in high risk chronic lymphocytic leukaemia
Single centre experience with bortezomib second line and beyond for myeloma
An audit on the use of lenalidomide in patients with myeloma
EBV viraemia after reduced intensity conditioning haematopoetic stem cell transplant incorporating alemtuzumab and its association with post transplant lymphoproliferative disorder
Audit of adequacy of bone marrow trephines reported by the haemato-oncology diagnostic service
Administration of bortezomib
Encouraging long-term survival outcomes in chronic lymphocytic leukaemia (CLL)
First line treatment of mantle cell lymphoma with high dose cytarabine and rituximab
The comprehensive geriatric assessment needs of older people with lymphoma
Accuracy in data collection of deaths due to myeloma in one centre
Management without radiotherapy may be an acceptable approach for stage 1 follicular lymphoma
Primary care management of stage A0 chronic lymphocytic leukaemia is safe and effective
The bi-specific antibody blinatumomab (MT103) induces apoptotic cell death in CLL B-cells via the activation of autologous T-cells
Factors affecting relative dose intensity in patients with Hodgkin lymphoma (HL) receiving doxorubicin, bleomycin, vinblastine and dacarbazine (ABVD) without granulocyte-colony stimulating factor (G-CSF) support
Outcome of secondary CNS lymphoma following autologous stem cell transplantation
CD80-IL2 expressing myeloma cells for immune gene therapy of multiple myeloma
Expanding the therapeutic potential of bromodomain inhibition in haematological cancer
Study of cell death in acute myeloid leukaemia cell lines following vorinostat treatment
Identification of prospective roles of ankyrin repeat and SOCS box proteins (ASBs) in acute myeloid leukaemia
Canonical Wnt signalling plays a key role in influencing mesodermal commitment and primitive erythropoiesis
Modulation of TGF-β1 induced quiescence to selectively eradicate chronic myeloid leukaemia stem cells
JAK2 V617F false negative rate in the UK NEQAS LI programme
ASXL1 mutations are infrequent in young patients with primary acute myeloid leukaemia
MicroRNAs expression on MDS with −7/7q deletion
Mechanism of Trib2 mediated degradation of C/EBP-α in acute myelogenous leukaemia
The ABCB1 3’UTR polymorphism (rs3842) is functionally significant in AML via effects on miR374a binding
Investigating synergism of Mcl-1 inhibition with first line therapies for leukaemia
Specific inhibition of autophagy enhances TKI-induced death in CML cells
Effect of BCR-ABL inhibition on induction of autophagy in chronic myeloid leukaemia cells
BCR-ABL inhibition induces expression of autophagy related genes in primary CML cells
Posaconazole prophylaxis obviates the need for empirical escalation of antifungal therapy during chemotherapy for acute myeloid leukaemia (AML) and high-risk myelodysplastic syndrome (HR-MDS)
Late toxicity of imatinib mesylate during therapy for chronic myeloid leukaemia (CML)
Cytogenetic abnormalities in acute myeloid leukaemia - the west of Scotland experience; early death continues to be significant in acute promyelocytic leukaemia
Time to initiation of intensive therapy has no impact on outcome in non-acute promyelocytic acute myeloid leukaemia. Experience from the West of Scotland Cancer Network
An audit of the investigation and management of suspected invasive fungal infection in a level 3 haematology unit
JAK2 v617f testing in the Northern Region, a review of 803 patient records
Evaluation of frequency of monitoring of chronic myeloid leukaemia patients in a general haematology department compared to European LeukaemiaNet guidelines
Outcome following relapse of acute myeloid leukaemia - a single centre experience
A population study demonstrating that the availability of second generation tyrosine kinase inhibitors has improved progression-free survival in chronic myeloid leukaemia
Single centre experience on the use of low dose subcutaneous cytarabine in treatment of patients with high-risk myelodysplastic syndrome and acute myeloid leukaemia
Novel design of VALOR, a phase 3 trial of vosaroxin or placebo in combination with cytarabine for patients with first relapsed or refractory acute myeloid leukaemia
Factors affecting outcome of salvage chemotherapy with FLAG+/− idarubicin for adults with relapsed/refractory AML
Addition of arsenic to ATRA and idarubicin upfront in APML
Does iron chelation therapy improve survival and reduce infections in patients with myelodysplastic syndrome?
Treatment of acute myeloid leukaemia in the elderly
Sweets syndrome and its association with myelodysplastic syndrome (MDS) - a single centre retrospective analysis of 27 cases
A UK single centre experience of 5-azacitidine in patients with myeloid malignancies, prior to NICE approval - a retrospective evaluation of 113 patients
Outcomes from allogeneic stem cell transplant compared to consolidation chemotherapy in acute myeloid leukaemia (AML) patients with FLT3 internal tandem duplications (ITD) - a single transplant centre study
Audit of telephone calls to an anticoagulant clinic
An audit of the appropriateness of VTE prophylaxis prescribing on a general surgical ward
A 6 months audit looking at the timing of haematology Nurse Specialists involvement for people with a newly diagnosed haematological malignancy
High risk haematology at a low risk antenatal clinic
A retrospective analysis of the diagnosis of type 1 von Willebrand disease in children
Cutaneous manifestations in childhood leukaemia
No prognostic impact of CRLF2 deregulation in childhood acute lymphoblastic leukaemia treated according to UK ALL 2003 protocol
The impact of pain on executive functioning in young people with sickle cell anaemia
Implementation of the new born screening programme for haemoglobinopathies in Scotland
Abstract Withdrawn
A cohort study of sleep disordered breathing in preschool children with sickle cell disease
Comparison of PCR & flow cytometry MRD detection in patients with relapse acute lymphoblastic leukaemia (ALL) treated in ALLR3 trial
Molecular versus flow cytometric MRD analysis - is there an explanation for discrepancies?
West Midlands population-based report of childhood AML outcome over a 6 years period
Iron deficiency anaemia as a cause of severe anaemia (Hb 5 ≤ g/dl) in children ≤16 years; results from an East London Institution
Automated exchange transfusions for sickle cell disease are safe and feasible using peripheral access in the paediatric population
Serious adverse events of UKALL 2003
A new haemoglobin variant with an extended beta chain due to an insertion of CCAGT at the position 375-376
Addition of hydroxyurea to transfusion programme to treat progressive cerebral vasculopathy
Acute pain management protocols in adult sickle cell patients - audit of observation frequency following administration of opiate analgesia
Use of individualised acute pain management protocols in adult sickle cell patients - a single centre experience
Reduced fertility potential in female patients with sickle cell disease
Audit of assessment and management of patients presenting with sickle vaso-occlusive crisis to City Hospital Birmingham
Sickle cell crisis
Clinical audit
Predictors of length of stay and time to readmission in adult patients with sickle cell disease - a single institution experience in the UK
Fifty-two percentage reduction in thalassaemia major patients with high liver iron concentration using FerriScan monitoring at the Whittington Hospital
West of Scotland audit on granulocyte transfusions
Immunoglobulin project
Fresh frozen plasma for abnormal coagulation tests - are we getting it right?
Transfusion safety in patients requiring irradiatied blood components
Errors in administration of anti-D immunoglobulin to prevent RhD haemolytic disease of the fetus and newborn
Is centralization of pathology services really the way forward?
Use of FFP for paediatric patients
An audit of red-cell usage and transfusion thresholds for haemato-oncology in-patients in a UK tertiary centre
Audit on the compliance with the guidelines for the use of irradiated blood components
Detection of incorrect blood component transfusions utilising electronic bedside verification
Testing patients for immunoglobulin a deficiency
D positive donor kidneys transplanted into D negative recipients
Audit of the use of prothrombin complex concentrate (octaplex) in a large tertiary hospital
Alloantibody formation in regularly transfused young patients (aged ≤ 21 years) with sickle cell disease - a single centre review
UK NEQAS LI BCR-ABL1 Quantitation Programme
The Canadian man with two blood groups
An audit of BCSH guidelines
Peripheral blood stem cell mobilisation during apheresis may be a significant contributor to harvesting yield
The role of targeted antenatal screening in foetal and neonatal alloimmune thrombocytopenia (FNAIT)
Pre-hospital care standard operating procedure - use of human prothrombin complex (octaplex®)
The efficiency of COBE spectra apheresis machine in collecting PBSC
Selected myeloma patients benefit from renal transplantation
First remission autologous stem cell transplantation (ASCT) with BCNU/thiotepa shows good response in patients with CNS lymphoma
Autologous stem cell transplantation in patients with severe renal impairment. A single centre experience
Autologous stem cell transplantation can improve the quality of response in lymphoplasmacytic lymphoma/waldenstrom macroglobulinaemia with a median time to best response of 5 months
Vitamin D deficiency at the time of HSCT may be safely reversed by high dose vitamin
Exploiting CD8β mutations which increase TCR avidity to improve the function of genetically modified T cells for immunotherapy
Enhancing the efficacy of T cell receptor (TCR) gene therapy by co-transfer of TCR and additional CD3 molecules into CD4+ T cells
Reduced immuno-suppression