The failure of torcetrapib
Principles of Safety Pharmacology
Zebrafish
Adrenaline reveals the torsadogenic effect of combined blockade of potassium channels in anaesthetized guinea pigs
Predicting drug-induced changes in QT interval and arrhythmias
Dose–response effects of sotalol on cardiovascular function in conscious, freely moving cynomolgus monkeys
Predicting QT prolongation in humans during early drug development using hERG inhibition and an anaesthetized guinea-pig model
The cardiovascular and pharmacokinetic profile of dofetilide in conscious telemetered beagle dogs and cynomolgus monkeys
Torcetrapib-induced blood pressure elevation is independent of CETP inhibition and is accompanied by increased circulating levels of aldosterone
The effect of changes in core body temperature on the QT interval in beagle dogs
Involvement of organic anion transporting polypeptides in the toxicity of hydrophilic pravastatin and lipophilic fluvastatin in rat skeletal myofibres
International Life Sciences Institute (Health and Environmental Sciences Institute, HESI) initiative on moving towards better predictors of drug-induced torsades de pointes
Cellular basis of drug-induced torsades de pointes
The impact of varying autonomic states on the dynamic beat-to-beat QT–RR and QT–TQ interval relationships
In vitro models of proarrhythmia
Literature-based evaluation of four ‘hard endpoint’ models for assessing drug-induced torsades de pointes liability
Sensitive and reliable proarrhythmia in vivo animal models for predicting drug-induced torsades de pointes in patients with remodelled hearts
Strategies to reduce the risk of drug-induced QT interval prolongation
Key clinical considerations for demonstrating the utility of preclinical models to predict clinical drug-induced torsades de pointes
Moving towards better predictors of drug-induced torsades de pointes