Challenges for and current status of research into positive modulators of AMPA receptors
Signal transduction by protease–activated receptors
High–throughput screening and small animal models, where are we?
Mitochondria as pharmacological targets
Isoflurane protects cardiomyocytes and mitochondria by immediate and cytosol–independent action at reperfusion
Methylenedioxymethamphetamine inhibits mitochondrial complex I activity in mice : a possible mechanism underlying neurotoxicity
The metabolic enhancer piracetam ameliorates the impairment of mitochondrial function and neurite outgrowth induced by ß–amyloid peptide
New drugs for neglected infectious diseases : Chagas' disease
Novel ruthenium complexes as potential drugs for Chagas's disease : enzyme inhibition and in vitro / in vivo trypanocidal activity
Nitric oxide donor trans– [RuCl([15]aneN4)NO]2+ as a possible therapeutic approach for Chagas' disease
Atomoxetine acts as an NMDA receptor blocker in clinically relevant concentrations
A novel antagonist of the prostaglandin E2 EP4 receptor inhibits Th1 differentiation and Th17 expansion and is orally active in arthritis models
Increased brain damage after ischaemic stroke in mice lacking the chemokine receptor CCR5
Selective α7 nicotinic acetylcholine receptor agonists worsen disease in experimental colitis
Pre–clinical properties of the α4β2 nicotinic acetylcholine receptor partial agonists varenicline, cytisine and dianicline translate to clinical efficacy for nicotine dependence
Ouabain attenuates cardiotoxicity induced by other cardiac steroids
Disruption of cellular cholesterol transport and homeostasis as a novel mechanism of action of membrane–targeted alkylphospholipid analogues
A novel role for the metabotropic glutamate receptor–7 : modulation of faecal water content and colonic electrolyte transport in the mouse
Shikonin reduces oedema induced by phorbol ester by interfering with IκBα degradation thus inhibiting translocation of NF–κB to the nucleus
Estimation of binding rate constants using a simultaneous mixed–effects method : application to monoamine transporter reuptake inhibitor reboxetine
Pharmacological characterization of the first potent and selective antagonist at the cysteinyl leukotriene 2 (CysLT2) receptor
Enhancement of inflammatory mediator release by β2–adrenoceptor agonists in airway epithelial cells is reversed by glucocorticoid action