Renin–angiotensin–aldosterone system blockade for cardiovascular diseases
The PI–PLC inhibitor U–73122 is a potent inhibitor of the SERCA pump in smooth muscle
The phospholipase C inhibitor U–73122 inhibits Ca2+ release from the intracellular sarcoplasmic reticulum Ca2+ store by inhibiting Ca2+ pumps in smooth muscle
Block and allosteric modulation of GABAergic currents by oenanthotoxin in rat cultured hippocampal neurons
Effects of ionotropic glutamate receptor antagonists on rat dural artery diameter in an intravital microscopy model
Failure of Bay K 8644 to induce RhoA kinase–dependent calcium sensitization in rabbit blood vessels
Acurhagin–C, an ECD disintegrin, inhibits integrin αvβ3–mediated human endothelial cell functions by inducing apoptosis via caspase–3 activation
2,3′,4,4′,5′–Pentamethoxy– trans –stilbene, a resveratrol derivative, inhibits colitis–associated colorectal carcinogenesis in mice
Sublethal concentrations of the platinum(II) complex [Pt( O , O ′–acac)(γ–acac)(DMS)] alter the motility and induce anoikis in MCF–7 cells
Histamine inhibits adhesion molecule expression in human monocytes, induced by advanced glycation end products, during the mixed lymphocyte reaction
AF–353, a novel, potent and orally bioavailable P2X3/P2X2/3 receptor antagonist
Effects of combination therapy with montelukast and carbocysteine in allergen–induced airway hyperresponsiveness and airway inflammation
The contribution of reactive oxygen species and p38 mitogen–activated protein kinase to myofilament oxidation and progression of heart failure in rabbits
A series of structurally novel heterotricyclic α–amino–3–hydroxyl–5–methyl–4–isoxazole–propionate receptor–selective antagonists
Chemo–nociceptive signalling from the colon is enhanced by mild colitis and blocked by inhibition of transient receptor potential ankyrin 1 channels
Increased morphine analgesia and reduced side effects in mice lacking the tac1 gene
Differences in the expression of endogenous efflux transporters in MDR1 –transfected versus wildtype cell lines affect P–glycoprotein mediated drug transport
The transient receptor potential channel antagonist SKF96365 is a potent blocker of low–voltage–activated T–type calcium channels
Differential sensitivity of basal and acetylcholine–induced activity of nitric oxide to blockade by asymmetric dimethylarginine in the rat aorta
Haemin–enhanced expression of haem oxygenase–1 stabilizes erythrocyte–induced vulnerable atherosclerotic plaques
Openers of small conductance calcium–activated potassium channels selectively enhance NO–mediated bradykinin vasodilatation in porcine retinal arterioles
Trace amines depress D2–autoreceptor–mediated responses on midbrain dopaminergic cells
Molecular determinants of state–dependent block of voltage–gated sodium channels by pilsicainide
Investigating the interaction of McN–A–343 with the M1 muscarinic receptor using its nitrogen mustard derivative and ACh mustard
Co–administration of ibuprofen and nitric oxide is an effective experimental therapy for muscular dystrophy, with immediate applicability to humans
β2–adrenoceptor agonist clenbuterol reduces infarct size and myocardial apoptosis after myocardial ischaemia/reperfusion in anaesthetized rats