How can we improve our understanding of cardiovascular safety liabilities to develop safer medicines?
Drug targeting of sphingolipid metabolism: sphingomyelinases and ceramidases
The histamine H3 receptor: from discovery to clinical trials with pitolisant
Biotransformation of 6-thioguanine in inflammatory bowel disease patients: a comparison of oral and intravenous administration of 6-thioguanine
Different sensitivities of rat skeletal muscles and brain to novel anti-cholinesterase agents, alkylammonium derivatives of 6-methyluracil (ADEMS)
Inhibitory effect of caffeine on pacemaker activity in the oviduct is mediated by cAMP-regulated conductances
The cardioprotective efficacy of TVP1022 in a rat model of ischaemia/reperfusion
Balloon catheter injury abolishes phenylephrine-induced relaxation in the rat contralateral carotid
Distinct tachykinin NK1 receptor function in primate nucleus tractus solitarius neurons is dysregulated after second-hand tobacco smoke exposure
Evidence for a differential opioidergic involvement in the analgesic effect of antidepressants: prediction for efficacy in animal models of neuropathic pain?
Telmisartan, ramipril and their combination improve endothelial function in different tissues in a murine model of cholesterol-induced atherosclerosis
20-Hydroxyeicosatetraenoic acid inhibits ATP-induced COX-2 expression via peroxisome proliferator activator receptor-α in vascular smooth muscle cells
Differential reactivity of human mammary artery and saphenous vein to prostaglandin E2: Implication for cardiovascular grafts
In vitro and in vivo evaluation of the anti-angiogenic actions of 4-hydroxybenzyl alcohol
Protein kinase C–independent inhibition of arterial smooth muscle K+ channels by a diacylglycerol analogue
Protein kinase C phosphorylates the cAMP response element binding protein in the hypothalamic paraventricular nucleus during morphine withdrawal
Resveratrol rescues cAMP-dependent anionic transport in the cystic fibrosis pancreatic cell line CFPAC1