Different tests for a difference: how do we do research?
What makes the α1A-adrenoceptor gene express the α1L-adrenoceptor functional phenotype?
Phenotype pharmacology of lower urinary tract α1-adrenoceptors
Cyclosporin A and cardioprotection: from investigative tool to therapeutic agent
Tau-targeted treatment strategies in Alzheimer's disease
OATPs, OATs and OCTs: the organic anion and cation transporters of the SLCO and SLC22A gene superfamilies
Cyclic nucleotide phosphodiesterase (PDE) isozymes as targets of the intracellular signalling network: benefits of PDE inhibitors in various diseases and perspectives for future therapeutic developments
The evolving science of detection of ‘blood doping’
TLR4-MyD88 signalling: a molecular target for alcohol actions
Inhibiting the TLR4-MyD88 signalling cascade by genetic or pharmacological strategies reduces acute alcohol-induced sedation and motor impairment in mice
Endothelin and bradykinin: ‘brothers-in-arms’ in Chagas vasculopathies?
Trypanosoma cruzi invades host cells through the activation of endothelin and bradykinin receptors: a converging pathway leading to chagasic vasculopathy
Azithromycin distinctively modulates classical activation of human monocytes in vitro
Pentoxifylline aggravates fatty liver in obese and diabetic ob/ob mice by increasing intestinal glucose absorption and activating hepatic lipogenesis
Treatment of depressive-like behaviour in Huntington's disease mice by chronic sertraline and exercise
Angiotensin-(1-7) inhibits epidermal growth factor receptor transactivation via a Mas receptor-dependent pathway
Pharmacokinetics and in vivo potency of soluble epoxide hydrolase inhibitors in cynomolgus monkeys
Modulating human proteinase activated receptor 2 with a novel antagonist (GB88) and agonist (GB110)
Dynamic monitoring of beating periodicity of stem cell-derived cardiomyocytes as a predictive tool for preclinical safety assessment
β2-Adrenoceptors increase translocation of GLUT4 via GPCR kinase sites in the receptor C-terminal tail
Long-term treatment with ivabradine in post-myocardial infarcted rats counteracts f-channel overexpression
TASK1 (K2P3.1) K+ channel inhibition by endothelin-1 is mediated through Rho kinase-dependent phosphorylation
Activation of transient receptor potential A1 by a non-pungent capsaicin-like compound, capsiate
Long-lasting neuroprotection and neurological improvement in stroke models with new, potent and brain permeable inhibitors of poly(ADP-ribose) polymerase
Non-bronchodilating mechanisms of tiotropium prevent airway hyperreactivity in a guinea-pig model of allergic asthma
5-HT receptors as novel targets for optimizing pigmentary responses in dorsal skin melanophores of frog, Hoplobatrachus tigerinus
A naturally occurring naringenin derivative exerts potent bone anabolic effects by mimicking oestrogen action on osteoblasts
Clozapine, but not haloperidol, enhances glial d-serine and L-glutamate release in rat frontal cortex and primary cultured astrocytes
Inhibiting fatty acid amide hydrolase normalizes endotoxin-induced enhanced gastrointestinal motility in mice
A β-amyloid oligomer directly modulates P/Q-type calcium currents in Xenopus oocytes
TM-25659 enhances osteogenic differentiation and suppresses adipogenic differentiation by modulating the transcriptional co-activator TAZ
Effects of atorvastatin metabolites on induction of drug-metabolizing enzymes and membrane transporters through human pregnane X receptor