Themed section: molecular pharmacology of GPCRs
GPCR expression in tissues and cells: Are the optimal receptors being used as drug targets?
Pharmacological modulation of chemokine receptor function
Constitutive formation of an RXFP1-signalosome: a novel paradigm in GPCR function and regulation
Biased signalling and allosteric machines: new vistas and challenges for drug discovery
Behind the curtain: cellular mechanisms for allosteric modulation of calcium-sensing receptors
The orexin receptor OX1R in colon cancer: a promising therapeutic target and a new paradigm in G protein-coupled receptor signalling through ITIMs
Lifting the lid on GPCRs: the role of extracellular loops
Mechanisms of rapid opioid receptor desensitization, resensitization and tolerance in brain neurons
Regulation of GPCR activity, trafficking and localization by GPCR-interacting proteins
Corticosteroid-induced gene expression in allergen-challenged asthmatic subjects taking inhaled budesonide
Ketamine-induced ventricular structural, sympathetic and electrophysiological remodelling: pathological consequences and protective effects of metoprolol
Different in vitro and in vivo profiles of substituted 3-aminopropylphosphinate and 3-aminopropyl(methyl)phosphinate GABAB receptor agonists as inhibitors of transient lower oesophageal sphincter relaxation
Cannabinoid CB2 receptors modulate ERK-1/2 kinase signalling and NO release in microglial cells stimulated with bacterial lipopolysaccharide
A novel fluorescent histamine H1 receptor antagonist demonstrates the advantage of using fluorescence correlation spectroscopy to study the binding of lipophilic ligands
Structure-activity relationships of vanilloid receptor agonists for arteriolar TRPV1
Ursolic acid induces apoptosis in human leukaemia cells and exhibits anti-leukaemic activity in nude mice through the PKB pathway
Antiplatelet and antithrombotic effect of F 16618, a new thrombin proteinase-activated receptor-1 (PAR1) antagonist
Identification of drugs and drug metabolites as substrates of multidrug resistance protein 2 (MRP2) using triple-transfected MDCK-OATP1B1-UGT1A1-MRP2 cells
Predicting the emetic liability of novel chemical entities: a comparative study
Inhibitory effect of bufalin and cinobufagin on steroidogenesis via the activation of ERK in human adrenocortical cells
Roflumilast inhibits the release of chemokines and TNF-α from human lung macrophages stimulated with lipopolysaccharide
A novel angiopoietin-derived peptide displays anti-angiogenic activity and inhibits tumour-induced and retinal neovascularization
Polymorphisms of ADORA2A modulate psychomotor vigilance and the effects of caffeine on neurobehavioural performance and sleep EEG after sleep deprivation
Hydrogen sulphide-releasing diclofenac derivatives inhibit breast cancer-induced osteoclastogenesis in vitro and prevent osteolysis ex vivo
Potent anti-inflammatory effect of a novel furan-2,5-dione derivative, BPD, mediated by dual suppression of COX-2 activity and LPS-induced inflammatory gene expression via NF-κB inactivation
d-Amino acid oxidase-mediated increase in spinal hydrogen peroxide is mainly responsible for formalin-induced tonic pain
Role of 5-HT1 receptor subtypes in the modulation of pain and synaptic transmission in rat spinal superficial dorsal horn
Modulation of mouse gastrointestinal motility by allyl isothiocyanate, a constituent of cruciferous vegetables ( Brassicaceae ): evidence for TRPA1-independent effects
TNF-α-induces airway hyperresponsiveness to cholinergic stimulation in guinea pig airways
Role of endothelin-1 in the hyper-responsiveness to nitrovasodilators following acute NOS inhibition
Comparative effects of different modes of renin angiotensin system inhibition on hypercholesterolaemia-induced atherosclerosis