Categorized or continuous? Strength of an association – and linear regression
MDMA and 5-HT neurotoxicity : the empirical evidence for its adverse effects in humans – no need for translation
Ecstasy cannot be assumed to be 3,4-methylenedioxyamphetamine (MDMA)
Lost in translation : preclinical studies on 3,4-methylenedioxymethamphetamine provide information on mechanisms of action, but do not allow accurate prediction of adverse events in humans
Peripheral neural targets in obesity
Bad statistical practice in pharmacology (and other basic biomedical disciplines) : you probably don't know P
Monoacylglycerol lipase – a target for drug development?
Neuroprotective and neurotrophic actions of glucagon-like peptide-1 : an emerging opportunity to treat neurodegenerative and cerebrovascular disorders
The successes and limitations of preclinical studies in predicting the pharmacodynamics and safety of cell-surface-targeted biological agents in patients
Sphingosine kinase : a key to solving the ‘French Paradox’?
Resveratrol dimers are novel sphingosine kinase 1 inhibitors and affect sphingosine kinase 1 expression and cancer cell growth and survival
BAY 41-2272, a soluble guanylate cyclase agonist, activates human mononuclear phagocytes
Concomitant facilitation of GABAA receptors and KV7 channels by the non-opioid analgesic flupirtine
Key role of PI3Kγ in monocyte chemotactic protein-1-mediated amplification of PDGF-induced aortic smooth muscle cell migration
A novel μ-conopeptide, CnIIIC, exerts potent and preferential inhibition of NaV1.2/1.4 channels and blocks neuronal nicotinic acetylcholine receptors
Crizotinib (PF-02341066) reverses multidrug resistance in cancer cells by inhibiting the function of P-glycoprotein
The cholecystokinin CCK2 receptor antagonist, JNJ-26070109, inhibits gastric acid secretion and prevents omeprazole-induced acid rebound in the rat
Role of mixed ion channel effects in the cardiovascular safety assessment of the novel anti-MRSA fluoroquinolone JNJ-Q2
Natural triterpenes modulate immune-inflammatory markers of experimental autoimmune encephalomyelitis : therapeutic implications for multiple sclerosis
The omega-3 polyunsaturated fatty acid eicosapentaenoic acid inhibits mouse MC-26 colorectal cancer cell liver metastasis via inhibition of PGE2-dependent cell motility
Hydrogen sulfide-induced mechanical hyperalgesia and allodynia require activation of both Cav3.2 and TRPA1 channels in mice