Exploring avidity: understanding the potential gains in functional affinity and target residence time of bivalent and heterobivalent ligands
Dual effect of morphine in long-term social memory in rat
Soluble epoxide hydrolase inhibitor, TUPS, protects against isoprenaline-induced cardiac hypertrophy
GABAB receptor subtypes differentially modulate synaptic inhibition in the dentate gyrus to enhance granule cell output
Modulation of the ASK1–MKK3/6–p38/MAPK signalling pathway mediates sildenafil protection against chemical hypoxia caused by malonate
Citrus fruit and fabacea secondary metabolites potently and selectively block TRPM3
Effects of etravirine on the pharmacokinetics and pharmacodynamics of warfarin in rats
The antibiotic azithromycin is a motilin receptor agonist in human stomach: comparison with erythromycin
Tolerance to nitroglycerin through proteasomal down-regulation of aldehyde dehydrogenase-2 in a genetic mouse model of ascorbate deficiency
Treatment with the cytochrome P450 ω-hydroxylase inhibitor HET0016 attenuates cerebrovascular inflammation, oxidative stress and improves vasomotor function in spontaneously hypertensive rats
Morphine administration modulates expression of Argonaute 2 and dopamine-related transcription factors involved in midbrain dopaminergic neurons function
Hydrogen sulphide-induced relaxation of porcine peripheral bronchioles
Antagonism of P2Y1-induced vasorelaxation by acyl CoA: a critical role for palmitate and 3′-phosphate
The constitutive androstane receptor activator 4-[(4R,6R)-4,6-diphenyl-1,3-dioxan-2-yl]-N,N-dimethylaniline inhibits the gluconeogenic genes PEPCK and G6Pase through the suppression of HNF4α and FOXO1 transcriptional activity
Suppression of Toll-like receptor 4 activation by caffeic acid phenethyl ester is mediated by interference of LPS binding to MD2
Protein phosphatase 1 coordinates CFTR-dependent airway epithelial HCO3− secretion by reciprocal regulation of apical and basolateral membrane Cl−-HCO3− exchangers
The contribution of the endogenous TRPV1 ligands 9-HODE and 13-HODE to nociceptive processing and their role in peripheral inflammatory pain mechanisms
Olesoxime protects embryonic cortical neurons from camptothecin intoxication by a mechanism distinct from BDNF
Regulation of carboxylesterase-2 expression by p53 family proteins and enhanced anti-cancer activities among 5-fluorouracil, irinotecan and doxazolidine prodrug
Unravelling the mechanism of action of NS9283, a positive allosteric modulator of (α4)3(β2)2 nicotinic ACh receptors