Multiple role of 3-mercaptopyruvate sulfurtransferase: antioxidative function, H2S and polysulfide production and possible SOx production
Oxaliplatin-induced enteric neuronal loss and intestinal dysfunction is prevented by co-treatment with BGP-15
Knockdown of the transcript of ERK in the brain modulates hypothalamic neuropeptide-mediated appetite control in amphetamine-treated rats
Xenopus-derived glucagon-like peptide-1 and polyethylene-glycosylated glucagon-like peptide-1 receptor agonists: long-acting hypoglycaemic and insulinotropic activities with potential therapeutic utilities
Usefulness of knockout mice to clarify the role of the opioid system in chronic pain
Role of p62/SQSTM1 beyond autophagy: a lesson learned from drug-induced toxicity in vitro
The novel, potent and highly selective 5-HT4 receptor agonist YH12852 significantly improves both upper and lower gastrointestinal motility
Opioid-induced inhibition of the human 5-HTand noradrenaline transporters in vitro: link to clinical reports of serotonin syndrome
Achyranthes bidentata polypeptide protects dopaminergic neurons from apoptosis in Parkinson's disease models both in vitro and in vivo
4-Aminopyridine: a pan voltage-gated potassium channel inhibitor that enhances Kv7.4 currents and inhibits noradrenaline-mediated contraction of rat mesenteric small arteries
Potential contribution of SET and c-MYC deregulation to promote extracellular matrix remodelling in hepatocellular carcinoma
Differential involvement of ipsilateral and contralateral spinal cord astrocyte D-serine in carrageenan-induced mirror-image pain: role of σ1 receptors and astrocyte gap junctions
Inhibition of acid-sensing ion channels by diminazene and APETx2 evoke partial and highly variable antihyperalgesia in a rat model of inflammatory pain
Tauroursodeoxycholic acid inhibits intestinal inflammation and barrier disruption in mice with non-alcoholic fatty liver disease
Phages of life – the path to pharma
GI-530159, a novel, selective, mechanosensitive two-pore-domain potassium (K2P) channel opener, reduces rat dorsal root ganglion neuron excitability
PRN473, an inhibitor of Bruton's tyrosine kinase, inhibits neutrophil recruitment via inhibition of macrophage antigen-1 signalling
Up-regulation of PYK2/PKCα-dependent haem oxygenase-1 by CO-releasing molecule-2 attenuates TNF-α-induced lung inflammation
Wheel running during chronic nicotine exposure is protective against mecamylamine-precipitated withdrawal and up-regulates hippocampal α7 nACh receptors in mice
Microbial biotransformations in the human distal gut
Towards functional selectivity for α6β3γ2 GABAA receptors: a series of novel pyrazoloquinolinones
Tetramethylpyrazine nitrone activates the BDNF/Akt/CREB pathway to promote post-ischaemic neuroregeneration and recovery of neurological functions in rats
Immune-pineal axis – acute inflammatory responses coordinate melatonin synthesis by pinealocytes and phagocytes
Calcimimetic and calcilytic therapies for inherited disorders of the calcium-sensing receptor signalling pathway
VPAC1 and VPAC2 receptor activation on GABA release from hippocampal nerve terminals involve several different signalling pathways
Chronic treatment with novel nanoformulated micelles of rapamycin, Rapatar, protects diabetic heart against ischaemia/reperfusion injury
Effects of the kinase inhibitor sorafenib on heart, muscle, liver and plasma metabolism in vivo using non-targeted metabolomics analysis
Transient receptor potential vanilloid 1 inhibitors block laparotomy- and opioid-induced infarct size reduction in rats
Antidepressant-like effects of BU10119, a novel buprenorphine analogue with mixed κ/μ receptor antagonist properties, in mice
Regulation of Wnt/β-catenin signalling by tankyrase-dependent poly(ADP-ribosyl)ation and scaffolding
Targeting nociceptive transient receptor potential channels to treat chronic pain: current state of the field
G protein-coupled receptors not currently in the spotlight: free fatty acid receptor 2 and GPR35
BIO 300, a nanosuspension of genistein, mitigates pneumonitis/fibrosis following high-dose radiation exposure in the C57L/J murine model
Importance of the second extracellular loop for melatonin MT1 receptor function and absence of melatonin binding in GPR50
Dopamine D2 receptor signalling controls inflammation in acute pancreatitis via a PP2A-dependent Akt/NF-κB signalling pathway
Immuno-pharmacological characterization of group II metabotropic glutamate receptors controlling glutamate exocytosis in mouse cortex and spinal cord
Characterization of a rat model of bortezomib-induced painful neuropathy
Nucleoside/nucleotide reverse transcriptase inhibitors attenuate angiogenesis and lymphangiogenesis by impairing receptor tyrosine kinases signalling in endothelial cells
Pituitary adenylate cyclase-activating polypeptide receptors in the trigeminovascular system: implications for migraine
Epigenetic regulation of melatonin receptors in neuropsychiatric disorders
Early treatment with Resolvin E1 facilitates myocardial recovery from ischaemia in mice
Assembly and architecture of the Wnt/β-catenin signalosome at the membrane
Neonicotinoid insecticides differently modulate acetycholine-induced currents on mammalian α7 nicotinic acetylcholine receptors
Light-induced regulation of ligand-gated channel activity
GPCR signalling from within the cell
Opioid and hypocretin neuromodulation of ventral tegmental area neuronal subpopulations
M-type K+ channels in peripheral nociceptive pathways
α9- and α7-containing receptors mediate the pro-proliferative effects of nicotine in the A549 adenocarcinoma cell line
Melatonin: does it have utility in the treatment of haematological neoplasms?
Metabolic profiling of murine plasma reveals eicosapentaenoic acid metabolites protecting against endothelial activation and atherosclerosis
Sodium channels and pain: from toxins to therapies
Wnt signalling pathways in chronic lymphocytic leukaemia and B-cell lymphomas
Trimethylamine N-oxide: breathe new life
Inhibition of nuclear Wnt signalling: challenges of an elusive target for cancer therapy
Loops D, E and G in the Drosophila Dα1 subunit contribute to high neonicotinoid sensitivity of Dα1-chicken β2 nicotinic acetylcholine receptor
‘Lnc’-ing Wnt in female reproductive cancers: therapeutic potential of long non-coding RNAs in Wnt signalling
Melatonin receptors: molecular pharmacology and signalling in the context of system bias
P2X receptor channels in chronic pain pathways
l-Homocysteine-induced cathepsin V mediates the vascular endothelial inflammation in hyperhomocysteinaemia
Molecular regulation and pharmacological targeting of the β-catenin destruction complex
Changes in the plasma membrane in metabolic disease: impact of the membrane environment on G protein-coupled receptor structure and function
Reduced α4 subunit expression in α4+− and α4+−/β2+− nicotinic acetylcholine receptors alters α4β2 subtype up-regulation following chronic nicotine treatment
Understanding and improving photo-control of ion channels in nociceptors with azobenzene photo-switches
Inhibition of human N- and T-type calcium channels by an ortho-phenoxyanilide derivative, MONIRO-1
Using automated patch clamp electrophysiology platforms in pain-related ion channel research: insights from industry and academia
The fifth subunit of the (α4β2)2β2 nicotinic ACh receptor modulates maximal ACh responses
Reactive oxygen species: key regulators in vascular health and diseases
Melatonin in regulation of inflammatory pathways in rheumatoid arthritis and osteoarthritis: involvement of circadian clock genes
Recent advances in the development of T-type calcium channel blockers for pain intervention
Translation of WNT developmental programs into stem cell replacement strategies for the treatment of Parkinson's disease
Influence of opioids on immune function in patients with cancer pain: from bench to bedside
Hydrogen sulfide pretreatment improves mitochondrial function in myocardial hypertrophy via a SIRT3-dependent manner
The Dickkopf1-cytoskeleton-associated protein 4 axis creates a novel signalling pathway and may represent a molecular target for cancer therapy
Rationale for targeting the Wnt signalling modulator Dickkopf-1 for oncology
Winding back Wnt signalling: potential therapeutic targets for treating gastric cancers
The p21-activated kinase 1 (Pak1) signalling pathway in cardiac disease: from mechanistic study to therapeutic exploration
The dynamic interaction between pain and opioid misuse
Endoplasmic reticulum stress in the heart: insights into mechanisms and drug targets
Understanding structure–function relationships of the human neuronal acetylcholine receptor: insights from the first crystal structures of neuronal subunits
Pharmacological interventions in the Wnt pathway: inhibition of Wnt secretion versus disrupting the protein–protein interfaces of nuclear factors
Oxidized low-density lipoprotein stimulates epithelial sodium channels in endothelial cells of mouse thoracic aorta
Predictive mechanisms linking brain opioids to chronic pain vulnerability and resilience
Peripheral inflammation affects modulation of nociceptive synaptic transmission in the spinal cord induced by N-arachidonoylphosphatidylethanolamine
α-Conotoxins active at α3-containing nicotinic acetylcholine receptors and their molecular determinants for selective inhibition
Allostery at opioid receptors: modulation with small molecule ligands
Persistent activation of α7 nicotinic ACh receptors associated with stable induction of different desensitized states
Targeting multiple opioid receptors – improved analgesics with reduced side effects?
Opioid system and human emotions
Protein S-sulfhydration by hydrogen sulfide in cardiovascular system
Adrenomedullin 2/intermedin: a putative drug candidate for treatment of cardiometabolic diseases
Multiple targets for flecainide action: implications for cardiac arrhythmogenesis
The role of Hippo/yes-associated protein signalling in vascular remodelling associated with cardiovascular disease
Dietary salt blunts vasodilation by stimulating epithelial sodium channels in endothelial cells from salt-sensitive Dahl rats
μ opioid receptor, social behaviour and autism spectrum disorder: reward matters
Calcium channel modulation as a target in chronic pain control
Proteins and chemical chaperones involved in neuronal nicotinic receptor expression and function: an update
Insights into the function of opioid receptors from molecular dynamics simulations of available crystal structures
IL-21 promotes myocardial ischaemia/reperfusion injury through the modulation of neutrophil infiltration
Oxytocin and opioid addiction revisited: old drug, new applications
WNT signalling events near the cell membrane and their pharmacological targeting for the treatment of cancer
Calcium signalling through L-type calcium channels: role in pathophysiology of spinal nociceptive transmission
Metformin attenuates angiotensin II-induced TGFβ1 expression by targeting hepatocyte nuclear factor-4-α
Opioids and the immune system – friend or foe
Homology-guided mutational analysis reveals the functional requirements for antinociceptive specificity of collapsin response mediator protein 2-derived peptides
Orthosteric and allosteric potentiation of heteromeric neuronal nicotinic acetylcholine receptors
Single administration of recombinant IL-6 restores the gene expression of lipogenic enzymes in liver of fasting IL-6-deficient mice
Decursin enhances TRAIL-induced apoptosis through oxidative stress mediated- endoplasmic reticulum stress signalling in non-small cell lung cancers
Compound 9a, a novel synthetic histone deacetylase inhibitor, protects against septic injury in mice by suppressing MAPK signalling
α1B-Adrenoceptor signalling regulates bone formation through the up-regulation of CCAAT/enhancer-binding protein δ expression in osteoblasts
Role of EP2 and EP4 receptors in airway microvascular leak induced by prostaglandin E2
What is the evidence for the role of TRP channels in inflammatory and immune cells?
Time-dependent activation of prostacyclin and nitric oxide pathways during continuous i.v. infusion of serelaxin (recombinant human H2 relaxin)
The Warburg effect and drug resistance
The metabotropic glutamate 5 receptor is necessary for extinction of cocaine-associated cues
Fenofibrate inhibits atrial metabolic remodelling in atrial fibrillation through PPAR-α/sirtuin 1/PGC-1α pathway
Endothelin-1 suppresses insulin-stimulated Akt phosphorylation and glucose uptake via GPCR kinase 2 in skeletal muscle cells
Genipin alleviates sepsis-induced liver injury by restoring autophagy
Molecular mechanisms governing different pharmacokinetics of ginsenosides and potential for ginsenoside-perpetrated herb–drug interactions on OATP1B3
Rotigotine is a potent agonist at dopamine D1 receptors as well as at dopamine D2 and D3 receptors
Therapeutic action of 5-HT3 receptor antagonists targeting peritoneal macrophages in post-operative ileus
Preclinical development of AMG 139, a human antibody specifically targeting IL-23
Hydrogen peroxide stimulation of CFTR reveals an Epac-mediated, soluble AC-dependent cAMP amplification pathway common to GPCR signalling
The sphingosine 1-phosphate receptor agonist FTY720 is neuroprotective after cuprizone-induced CNS demyelination
Investigation of connexin 43 uncoupling and prolongation of the cardiac QRS complex in preclinical and marketed drugs
Overexpression of oxytocin receptors in the hypothalamic PVN increases baroreceptor reflex sensitivity and buffers BP variability in conscious rats
Ulinastatin activates haem oxygenase 1 antioxidant pathway and attenuates allergic inflammation
Convergent pharmacological mechanisms in impulsivity and addiction: insights from rodent models
Pharmacological manipulations in animal models of anorexia and binge eating in relation to humans
CFTR potentiators partially restore channel function to A561E-CFTR, a cystic fibrosis mutant with a similar mechanism of dysfunction as F508del-CFTR
Pharmacological regulators of autophagy and their link with modulators of lupus disease
PAR1-dependent COX-2/PGE2 production contributes to cell proliferation via EP2 receptors in primary human cardiomyocytes
Identification of an old antibiotic clofoctol as a novel activator of unfolded protein response pathways and an inhibitor of prostate cancer
Purinergic neuromuscular transmission in the gastrointestinal tract; functional basis for future clinical and pharmacological studies
Targeting multiple cannabinoid anti-tumour pathways with a resorcinol derivative leads to inhibition of advanced stages of breast cancer
Molecular basis of agonist docking in a human GPR103 homology model by site-directed mutagenesis and structure–activity relationship studies
Modelling cognitive affective biases in major depressive disorder using rodents
The compound BTB06584 is an IF1-dependent selective inhibitor of the mitochondrial F1Fo-ATPase
Using animal models to study post-partum psychiatric disorders
Developmental rodent models of fear and anxiety: from neurobiology to pharmacology
Modelling headache and migraine and its pharmacological manipulation
Cardiac responses to β-adrenoceptor stimulation is partly dependent on mitochondrial calcium uniporter activity
Sex differences in animal models of psychiatric disorders
Reconceptualizing sex, brain and psychopathology: interaction, interaction, interaction