Chronic pancreatitis – lessons learned
Helicobacter pylori infection and gastric cancer
Systematic review of endovenous laser treatment for varicose veins
Systematic review comparing laparoscopic and open repair for perforated peptic ulcer
Randomized clinical trial of vertical or transverse laparotomy for abdominal aortic aneurysm repair
Randomized clinical trial of postoperative fondaparinux versus perioperative dalteparin for prevention of venous thromboembolism in high-risk abdominal surgery
Multicentre validation study of sentinel node biopsy for staging in breast cancer
Treatment of loculated lactational breast abscess with a vacuum biopsy system
C5 complement inhibition attenuates shock and acute lung injury in an experimental model of ruptured abdominal aortic aneurysm
Surgery for clinical T3 carcinomas of the upper thoracic oesophagus and the need for new strategies
Role of liver function tests in predicting common bile duct stones in acute calculous cholecystitis
Adverse effects of radiofrequency ablation of liver tumours in the Netherlands
Primary endocrine tumours of the liver
Impact of visceral obesity on surgical outcome after laparoscopic surgery for rectal cancer
Comparison of the effects of nitric oxide donors and calcium channel blockers on the intrinsic myogenic tone of sheep isolated internal anal sphincter
Risk factors associated with ileal pouch-related fistula following restorative proctocolectomy
Prospective nationwide analysis of laparoscopic versus Lichtenstein repair of inguinal hernia
Subtotal parathyroidectomy with thymectomy for autonomous hyperparathyroidism after renal transplantation
Comparison of Surgical Risk Score, POSSUM and p-POSSUM in higher-risk surgical patients
Tolerance of uncertainty, extroversion, neuroticism and attitudes to randomized controlled trials among surgeons and physicians
Randomized clinical trial of routine preoperative duplex imaging before varicose vein surgery (Br J Surg 2005; 92: 688–694)
Randomized clinical trial of laparoscopic Nissen fundoplication compared with proton-pump inhibitors for treatment of chronic gastro-oesophageal reflux (Br J Surg 2005; 92: 695–699)
Validity of the Glasgow Aneurysm Score and the Hardman Index in predicting outcome after ruptured abdominal aortic aneurysm repair (Br J Surg 2005; 92: 570–573)
Ischaemic preconditioning in transplantation and major resection of the liver (Br J Surg 2005; 92: 528–538)
Cultivating a thinking surgeon
Scientific Surgery
Glutathione supplementation to University of Wisconsin solution causes endothelial dysfunction
A Phase III randomised control trial of G17DT for patients with advanced pancreatic cancer unsuitable or unwilling to take chemotherapy
A predictive role for Ets-2 and SRC-1 in endocrine resistant breast cancer
Nitric oxide augments the cytotoxicity of chemotherapeutic agents used in colorectal cancer
ABCA1 mRNA expression correlates with MMP-9 expression in atherosclerotic tissues
Gene expression profiling of diploid microsatellite-stable colorectal cancers with poor clinical outcome
Cyclooxygenase-2 inhibition decreases tumour growth by increasing apoptosis and inhibiting lymphangiogenesis in a xenograft model of breast cancer
C5 complement inhibitor attenuates shock and acute lung injury in a model of ruptured abdominal aortic aneurysm
The IL-10-1082 gene polymorphism
Measuring early adaptive response to 5-fluorocil therapy using FLT-positron emission tomography
A DNA fusion gene vaccine induces epitope-specific cytotoxic T cells able to kill human cells expressing pp65 of cytomegalovirus
Administration of a novel perioperative multiple heat shock protein-loaded dendritic cell vaccine significantly attenuates recurrent breast cancer growth in vivo
Two weeks' taurine supplementation reverses endothelial dysfunction in young male diabetic patients
Does preconditioning benefit claudicants?
Chemotactic cytokines are upregulated in abdominal aortic aneurysms
Differential P-selectin expression following hind limb ischaemia reperfusion injury
Glycine suppresses cytokine expression and improves bile flow in a rabbit model of liver warm ischaemia-reperfusion injury
Novel myocardial protection using an omega-3 fatty acid infusion
The adaptive response of the reticuloendothelial system to major liver resection in man
The effect of hydroxyethyl starches on splanchnic perfusion, systemic endotoxin exposure, endothelial activation and organ dysfunction during infrarenal abdominal aortic aneurysm surgery
A randomised double-blind controlled clinical trial to assess the effects of prophylactic N-acetylcysteine on liver injury during liver resection
P53 activation in hypoxia
Microarray analysis of contrasting invasive phenotypes in sporadic colorectal cancer
Dentifying genetic pathways during the evolution of docetaxel resistance in breast cancer cells
Mechanisms of inhibition of p53 function in tumours that express the Pax3 proto-oncogene
Upregulation of the receptor tyrosine kinase DDR1 may induce AKT activation in a model of local breast cancer recurrence
Promoter hypermethylation and transcriptional silencing of progesterone receptor B in breast carcinoma
The roles of CyclinE, Jab1 and archipelago in breast cancer cell cycle dysregulation
Vaccination against colorectal cancer
The human hedgehog interacting protein gene is aberrantly methylated in pancreatic cancer and is a mediator of hedgehog pathway activity in pancreatic carcinogenesis
The effect of acid pH and bile acids on NFκB in Barretts' oesphagus
Gastro-oesophageal reflux disease is associated with alteration of swallowing duration
Peritoneal cytokines and drain fluid upregulate tumour cell urokinase plasminogen activator receptor expression and stimulate invasion
Ileitis in ulcerative colitis is not a backwash
Immunological prevention of breast cancer metastasis using heparins
Gene expression responses to endogenous antioxidant activity in human vascular smooth muscle cells
Glucose control significantly enhances diabetic wound healing
Adenoviral-mediated over-expression of interleukin-10 recapitulates ‘scarless fetal wound healing’ in postnatal wounds
High levels of transforming growth factor-β in colorectal liver metastases may explain local immunosuppression
The effect of the COX-2 inhibitor, rofecoxib, on tumour size and dendritic cell phenotype in an experimental colorectal carcinoma model in BALB/c mice
A proteomic approach to docetaxel resistance in breast cancer cells
Apoptotic markers predict response to neo adjuvant chemotherapy in locally advanced breast cancer
High nuclear A100A6 (calcyclin) is significantly associated with poor survival in pancreatic cancer patients
The lower proliferation rate of screen-detected breast cancers underlies their better survival
Novel biomarkers in colorectal cancer
Aspirin represses NFκB-driven transcription of the ICAM-1 gene in colorectal cancer
Proteolysis inducing factor core peptide induces tumour cell proliferation
Glut1 expression and its correlation with pathological response in rectal cancer patients treated with neoadjuvant chemoradiotherapy
Evaluation of the Six-Shooter ligation device in the management of bleeding oesophageal varices
Conversion rates for laparoscopic cholecystectomy in England for the year 2001
Laparoscopic large-volume microwave tissue ablation of liver tumours
Endovascular aneurysm repair
A comparison between statistical modelling and artificial neural networks in predicting mortality following abdominal aortic aneurysm surgery
A non-randomised controlled trial of the clinical and cost-effectiveness of a supervised exercise programme for claudication
Immunotherapy of cancer using ex vivo generated dendritic cells pulsed with peptides of human telomerase reverse transcriptase
Identification of novel proteins in the pancreatic cancer microenvironment
Direct quantitation of antigen-reactive T cells following vaccination with anti-idiotype vaccine 105AD7 in patients with colorectal carcinoma and un-immunised controls
Functional proteomics profiling in colorectal cancer
Changes in prognostic and predictive marker expression during colorectal cancer surgery
The expression and distribution of vascular endothelial growth factor isoforms and their receptors in Dukes' Stage B colorectal cancer
Bcl-w expression does not occur until the adenoma stage of colorectal cancer development
Topical phenytoin gel (PG1124cc) can accelerate wound healing in a diabetic wound model
STAT signalling directs resolution of inflammation through NFκB inhibition
Glutamine preconditioning attenuates endotoxin-induced left ventricular dysfunction in mice
Neutrophil capture to P-selectin is inhibited by unfractioned heparin but not by component glucosamine residues or Fondaparinux using an in vitro flow assay model relevant to reperfusion injury
The effects of warm and cold ischaemia on vascular endothelial cells are preservation solution-dependent
Hydroxyethyl starch reduces the production of the inflammatory chemokine IL-8 from stimulated human umbilical vein endothelial cells
The influence of preservation solution on renal microvasculature during in situ cooling of kidneys from non-heart-beating donors
Curcumin protects hepatocytes via heme oxygenase 1 from simulated warm reperfusion but not after cold storage
ATP analysis in an in vitro rat renal transplant model
N-Acetylcysteine reduces liver warm ischaemia-reperfusion injury via modulation of nitric oxide metabolism
Insulin induces heme oxygenase-1 via the PI 3-kinase/Akt pathway
Effects of hypoxia-reoxygenation and ischaemic preconditioning on caspase-3 activation in human sinusoidal endothelial cells
Cytoimmunological surveillance in human cardiac transplantation with the neutrophil
Biological features of the carotid plaque predict distal embolisation during carotid endoluminal intervention
A single nucleotide polymorphism in the promoter region of the stomelysin-1 gene is associated with aortic aneurysm formation
Characterising the haemodynamics of lymphoedema of the lower limb
A hybrid bypass graft made from compliant poly(carbonate-urea)urethane scaffold, human smooth muscle and endothelial cells from the same patient
Modulation of the heparin response of human vascular smooth muscle cells by extracellular matrix
Decreased antioxidant vitamin concentration is a risk factor for recurrent carotid stenosis
A novel experimental model of recovery from moderate hind limb ischaemia in mice
IGFBP-3 differentially modulates the epidermal growth factor response of normal and malignant breast epithelial cells in a fibronectin-dependent manner via altered mitogen-activated protein kinase signalling
Differential patterns of E-selectin and VCAM expression on three human endothelial cell types
Expression of the calcium receptor in human breast cancer is predominant in patients developing bone metastases
Latent effects of fibronectin, α5β1-integrin, α5β5-integrin and the cytoskeleton regulate pancreatic carcinoma cell interleukin-8 secretion
Interactions between the epidermal growth factor receptor and tethered transforming growth factor alpha in a co-culture model
Changes in serum IL-10 and IL-12 levels pre- and postoperatively in breast cancer patients
Vascular endothelial growth factor (VEGF) expression in breast cancer microarray
Neuropilin-1 expression pattern in invasive breast cancer
Eradication of gastric carcinoma cells by targeting EpCam and CD3 using bispecific/trifunctional antibodies
Quorum sensing molecules