Protease-catalyzed incorporation of non-protein amino acids into peptides via the kinetically controlled approach

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Through the kinetically controlled approach, employing the methyl ester as an acyl donor, non-protein aliphatic amino acids were incorporated into peptides using papain in an aqueous buffer, while the incorporation of non-protein aromatic amino acids was achieved by exploiting α-chymotrypsin in an aqueous buffer or acetonitrile with low water content.

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