Anti-fungal effects of phenolic amides isolated from the root bark of Lycium chinense

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Four phenolic amides, dihydro-N-caffeoyltyramine (1), trans-N-feruloyloctopamine (2), trans-N-caffeoyltyramine (3), and cis-N-caffeoyltyramine (4), were isolated from an ethyl acetate extract of the root bark of Lycium chinense Miller. All had an anti-fungal effect; compounds 1-3 were potent at 5–10 μg ml−1 and were without hemolytic activity against human erythrocyte cells. Compound 4 was active at 40 μg ml−1. All four compounds impeded the dimorphic transition of pathogen, Candida albicans.

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