Topiramate's effects on alcohol use similar to FDA-approved drugs

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A meta-analysis of seven randomized controlled trials, comprising 1,125 patients, has found that the antiepileptic drug topiramate is moderately effective compared with placebo in reducing alcohol consumption in individuals with alcohol use disorders. Effect sizes in the examined trials were comparable to those for naltrexone and acamprosate, the most frequently studied of the medications approved by the Food and Drug Administration (FDA) for alcohol dependence.

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