Higher doses of SSRIs linked to better outcomes, more side effects

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A review and meta-analysis encompassing 40 randomized trials has concluded that higher doses of selective serotonin reuptake inhibitors (SSRIs) appear to result in slightly more improved outcomes in treating major depressive disorder. The meta-analysis also found, however, that higher doses generated more treatment dropouts due to side effects, which means that the decision to increase dosage requires a balancing of these factors. Results were published online Nov. 10, 2015 in the American Journal of Psychiatry.

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