Valproate, risperidone, and antibiotic levels

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The antiepileptic drug valproate is frequently used in the treatment of manic episodes, either as monotherapy or combined with lithium, carbamazepine, or antipsychotics. Drug interaction with valproate secondary to its ability to inhibit drug elimination, as well as induction of its metabolism by concurrently administered drugs, is commonly reported. In particular, the carbapenem antibiotics have been reported to interact with valproate, resulting in lower valproic acid concentrations and loss of seizure control.1

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