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The value of total creatine kinase and the isozymes for assessment of electric burns in seven patients was studied. The control group consisted of 15 patients with burns ranging from 5% to 70% of the body surface area. All patients with electric burns had marked elevation of total creatine kinase, the magnitude of the total enzyme elevation showing a strong relationship to the extent and number of extremity amputations required. Four of the seven patients had elevation of the MB (cardiac) fraction of isozyme, and each had significant abnormalities in the EKG.