Granulocyte Function: Current Knowledge and Methods of Assessment


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Abstract

The primary function of granulocytes is the defense against invading microorganisms. The “cellular equipment” of these cells makes them well suited for this role. Granulocytes are recruited from the bone marrow on demand and proliferate from progenitor cells after infection. Granulocytes are highly mobile and are capable of invading every tissue of the organism. They show positive chemotaxis, and this form of sensitivity is indispensable to the destruction of microorganisms. Granulocytes are highly phagocytic cells that contain microbicidal systems and a variety of digestive enzymes. These secretory cells are also probably responsible for amplification of inflammatory events. Granulocyte functions are reviewed in this article.

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