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Burn injuries are at risk of bacterial infection because of the damaged skin and reduced immune responses. Silver sulfadiazine, a potent antibacterial agent, is considered as a standard therapy for burn treatment. Recent advances in nanotechnology have had an immense impact on drug delivery systems particularly in burn healing. Lipid-based nanocarriers have been considered as efficient drug delivery systems for burn treatment. This review presents a comprehensive overview of silver sulfadiazine-based nanocarriers and their application in the conservative healing of burn wounds.