Cardiovascular disease remains the leading cause of death and disability in the developed world. Over the last several years, many noninvasive imaging techniques have been used to enhance the diagnosis of cardiac disease. One of these advances, multidetector computed tomographic angiography (CTA), has transformed computed tomography from a single-slice transaxial imaging modality to a true 3-dimensional imaging technique with the ability to acquire submillimeter volumetric data. These benefits enable novel applications of CTA for the assessment of cardiac and coronary anatomy that were not previously possible. In this report, we discuss evolving indications for coronary CTA, noncoronary cardiac CTA, and several potential future indications for cardiac CTA.