TGFβ signaling pathways and human diseases

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Abstract

Recent progress in deciphering the TGFβ pathway has uncovered a new signaling molecule, the Smads, and with this finding now gives us insights into how TGFβ-like signals are transmitted from outside the cell to the nucleus. As we learn more about how TGFβ regulates normal development, we also are gaining insights into diseases that are caused by mis-regulation or mutation of various components of the signaling pathways.

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