Feasibility and efficacy of 5-azacytidine used early in the therapy of adult acute nonlymphocytic leukemia: An ECOG pilot study

    loading  Checking for direct PDF access through Ovid


TEN OF 19 ADULT PATIENTS (53%) with acute nonlymphocytic leukemia achieved a complete remission (CR) after receiving combination therapy with daunorubicin and cytosine arabinoside. The early administration of 5-azacytidine to treatment failures did not enhance the CR rate. Patients gaining CR received six monthly cycles of single-agent chemotherapy (5-azacytidine, daunorubicin, and cytosine arabinoside) sequentially as consolidation therapy over the next 7 months and no subsequent maintenance therapy. The median duration of CR is 10 months which is similar to previous studies. The early administration of 4-azacytidine did not increase the duration of remission, but was not associated with significant toxicity.

    loading  Loading Related Articles