Usefulness of Thrombophilia Testing in Venous Thromboembolic Disease: Findings From the RIETE Registry

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Abstract

Background:

Information on thrombophilia risk factors for patients with upper extremity deep vein thrombosis (UEDVT) is limited. The genetic, acquired, and coagulation risk factors of an acute episode of lower EDVT (LEDVT) or UEDVT, either isolated or associated with pulmonary embolism (PE), were studied.

Materials and Methods:

A total of 4503 patients participated in a thrombophilia study. Odds ratio (OR) and 95% confidence intervals (Cls) were calculated.

Results:

Mean age of the participants was 55 ± 19 years. The risk of LEDVT or UEDVT, isolated or associated with PE, was calculated according to thrombophilia factors. We found association between LEDVT and factor V Leiden ([FVL]; OR: 1.8; 95% Cl 1.4–2.4) and resistance to activated protein C ([APC-R]; OR: 1.6; 95% Cl 1.1–2.4). The LEDVT + PE presented an association with PTG20210A (OR: 1.5; 95% CI 1.1–2.1). No association was found between the thrombophilic defects studied and UEDVT or UEDVT + PE.

Conclusions:

Both FVL and APC-R carriers had the risk of developing LEDVT. The PTG20210A carriers had the risk of developing LEDVT + PE. No thrombophilic defects studied presented risk factors for UEDVT or UEDVT + PE.

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