Increased membrane lipid peroxidation and decreased Na+/K+-ATPase activity in erythrocytes of patients with stable coronary artery disease

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Abstract

Objectives

We aimed to determine erythrocyte membrane lipid peroxidation levels and Na+/K+-ATPase activity in patients with and without coronary artery disease (CAD) documented by coronary angiography.

Design and methods

A total of 144 patients who had undergone coronary angiography were divided into a CAD group (n=82) and a non-CAD group (control group, n=62) according to the results of coronary angiography. Lipid peroxide levels in plasma and the erythrocyte membrane were measured using a fluorimetric method. Total antioxidant status and Na+/K+-ATPase activity in plasma were determined using spectrophotometric methods.

Results

Lipid peroxidation levels were significantly higher in the erythrocyte membrane of CAD patients compared with controls, whereas Na+/K+-ATPase activity was significantly lower in the erythrocyte membrane of CAD patients compared with controls. The coronary artery scores were correlated positively with membrane lipid peroxidation (r=0.324, P<0.001) and negatively with Na+/K+-ATPase activity (r=−0.302, P<0.001).

Conclusion

This study shows that the levels of membrane lipid peroxidation and Na+/K+-ATPase activity are correlated with the severity of CAD.

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