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This study aimed to assess the clinical outcomes and adverse events among patients with implantable cardiac defibrillators (ICDs) in cardiac rehabilitation programs.Data were compared for 42 consecutive patients with ICDs and 42 control patients matched by age, gender, and left ventricular ejection fraction without ICDs and enrolled in the same program.The number of cardiac rehabilitation exercise sessions for each group was 828 and 925, respectively. Only 1 patient experienced an ICD firing during exercise; there were no cardiac arrests and no deaths in either group. Compliance with cardiac rehabilitation was similar in both groups with most dropouts for nonmedical reasons and similar rates for cardiac-related reasons. Improvements in exercise capacity were similar between groups (30% in ICD patients and 37% in controls).Although larger studies are needed, these data suggest that supervised exercise training in patients with ICDs appears to be safe and effective.