The effect of vitamin D supplementation on plasma leptin/adiponectin ratio in diabetic individuals with different haptoglobin phenotypes


    loading  Checking for direct PDF access through Ovid

Abstract

AimThe present study was designed to evaluate the impact of high doses of vitamin D on plasma leptin/adiponectin ratio (LAR) and on glucose homeostasis parameters in diabetic individuals with different haptoglobin phenotypes.Materials and methodsIn a randomized, placebo-controlled study, 47 diabetic patients were assigned to two groups: group 1 received an oral supplementation of vitamin D daily at a dose of 1000 U/day and group 2 received matching placebo capsules. In addition, each group was divided into two subgroups by Hp phenotype: subgroup 1 included diabetic patients with the Hp 2-2 phenotype and subgroup 2 included non-Hp 2-2 patients.ResultsAfter 12 months, LAR decreased significantly from 3.6±2.5 to 2.3±1.5 (P=0.039) in patients with the Hp 2-2 phenotype and did not change significantly in non-Hp 2-2 diabetic patients receiving vitamin D. No change was detected in LAR in subgroups of patients receiving placebo.ConclusionHigh doses of vitamin D supplementation were associated with a decrease in LAR in diabetic patients with the Hp 2-2 phenotype.

    loading  Loading Related Articles