SIRT1 in Endothelial Cells as a Novel Target for the Prevention of Early Vascular Aging


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Abstract

As one of the main risk factors for cardiovascular diseases, ageing plays an important role in the alterations of vascular structure and function. Early vascular ageing refers to a condition in patients with impaired endothelial function and increased arterial stiffness that can be assessed before the overt clinical manifestations, such as hypertension and atherosclerosis. Both epidemiological and experimental data indicate that the biological age of endothelial cells in patients with cardiovascular diseases is older than their chronological age. In fact, endothelial senescence is present at the early stage of vascular ageing and contributes to the development of endothelial dysfunction and arterial stiffness. Sirtuin 1 (SIRT1), the mammalian ortholog of yeast longevity regulator Sir2, is a nicotinamide adenine dinucleotide (NAD+)-dependent protein deacetylase that elicits a variety of vasoprotective functions. Overexpression of SIRT1 in endothelium prevents cellular senescence, enhances vasodilatory responses, and attenuates ageing-induced vascular damages. The present review summarizes the recent progresses related to SIRT1-mediated beneficial effects on the prevention of early vascular ageing and discusses the potential of SIRT1 in endothelial cells as an antivascular ageing target.

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