A series of indolebutylamine derivatives were designed, synthesized, and evaluated as a novel class of selective ligands for the dopamine 3 receptor. The most potent compound 11q binds to dopamine 3 receptor with a Ki value of 124 nm and displays excellent selectivity over the dopamine 1 receptor and dopamine 2 receptor. Investigation based on structural information indicates that site S182 located in extracellular loop 2 may account for high selectivity of compounds. Interaction models of the dopamine 3 receptor-11q complex and structure-activity relationships were discussed by integrating all available experimental and computational data with the eventual aim to discover potent and selective ligands to dopamine 3 receptor.
Using a strategy that combines synthetic chemistry, binding assays and a set of computational approach, we designed a series of indolebutylamine derivatives as a new type of highly selective dopamine 3 receptor were identified and the structure-activity relationships was investigated to understand the recognition of this type of dopamine 3 receptor ligands.