Serendipitous Discovery of a Prodrug of a PARP-1 Inhibitor

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Abstract

During SAR development of previously reported pyrrolocarbazole 1, a potent PARP-1 inhibitor, compound 14, was discovered serendipitously to be a prodrug of compound 1.

Compound 14 behaves as a water-soluble prodrug of pyrrolocarbazole 1, a potent PARP-1 inhibitor.

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