We report herein the synthesis,α-glucosidase inhibition and docking studies for a series of 3–15 new flavones. A simple nucleophilic substitution reaction takes place between 3′hydroxyflavone (2) with halides to afford the new flavones. Chalcone (1), 3′hydroxyflavone (2) and the newly synthesized flavones (3–15) were being evaluated for their ability to inhibit activity ofα-glucosidase. Compounds 2, 3, 5, 7–10 and 13 showed good inhibitory activity with IC50 values ranging between 1.26 and 36.44μm as compared to acarbose (IC50 = 38.25 ± 0.12μm). Compounds 5 (5.45 ± 0.08μm), 7 (1.26 ± 0.01μm) and 8 (8.66 ± 0.08μm) showed excellent inhibitory activity, and this may be due to trifluoromethyl substitution that is common for these compounds. Compound 7, a 2,5-trifluoromethyl-substituted compound, recorded the highest inhibition activity, and it is thirty times better than the standard drug. Docking studies for compound 7 suggest that both trifluoromethyl substituents are well positioned in a binding pocket surrounded by Phe300, Phe177, Phe157, Ala278, Asp68, Tyr71 and Asp214. The ability of compound 7 to interact with Tyr71 and Phe177 is extremely significant as they are found to be important for substrates recognition byα-glucosidase.
Synthesis and α-glucosidase inhibition activity of new flavone ether derivatives (3–15).