The Management Strategy of Benign Solitary Intraductal Papilloma on Breast Core Biopsy


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Abstract

BackgroundIntraductal papilloma (IDP) is well-known as one of the common benign breast lesions requiring excision. However, treatment of IDP without atypia is controversial. The aim of our study was to determine the proper management of solitary IDP by core needle biopsy (CNB).Patients and MethodsWe retrospectively reviewed patients with solitary IDP confirmed by CNB from March 2003 to March 2015. We collected data about final pathology after excision, as well as clinical, histologic, and radiologic findings at initial diagnosis. The final pathology was categorized as benign or malignant. We evaluated the rate of upgrade to malignancy and factors associated with malignancy.ResultsWe identified 405 patients who presented benign solitary IDP by CNB. The mean age was 46.1 years (range, 15-86 years). In total, 135 patients underwent surgical excision, and 211 underwent vacuum-assisted excision. Of 346 patients, malignant lesions were found in 8 patients (2.3%): 7 underwent surgical excision, and 1 underwent vacuum-assisted excision. Only the size of IDP was significantly associated with cancer upgrade (P = .003).ConclusionsOur study shows that overall malignancy upgrade rate of benign solitary IDP after excision is very low (2.3%). Even when the size of IDP was less than 1 cm, the upgrade rate to cancer was only 0.9%. Therefore, for patients with small solitary IDP, we recommend close follow-up with ultrasound instead of excision.Micro-AbstractWe evaluated cancer upgrade rate of intraductal papilloma (IDP) without atypia after excision for 346 patients. Overall upgrade rate was 2.3%. Mass size was the only predictor for cancer. Higher upgrade rate was observed in patients with a larger mass (> 2 cm: 15.8%, 1-2 cm: 3.0%, and ≤ 1 cm: 0.9%). Our study suggested that small (≤ 1 cm) IDP without atypia could be followed-up.

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