Predictive Value of MSH2 Gene Expression in Colorectal Cancer Treated with Capecitabine

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Abstract

Purpose:

The objective of the present study was to evaluate the gene expression of the DNA mismatch repair gene MSH2 as a predictive marker in advanced colorectal cancer (CRC) treated with first-line capecitabine.

Patients and Methods:

Microdissection of paraffin-embedded tumor tissue, RNA extraction, and quantitative polymerase chain reaction were performed on tumors obtained from 37 patients with advanced CRC.

Results:

The median relative gene expression of MSH2 was 0.65 (quartiles 0.5–0.8) in nonresponders and 1.25 (quartiles 0.92–1.38) for responders (P = 0.038). High expression of MSH2 was associated with a hazard ratio of 0.5 (95% confidence interval, 0.23–1.11; P = 0.083) in survival analysis.

Conclusion:

The higher gene expression of MSH2 in responders and the trend for predicting overall survival indicates a predictive value of this marker in the treatment of advanced CRC with capecitabine.

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