Predictive Value of MSH2 Gene Expression in Colorectal Cancer Treated with Capecitabine

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The objective of the present study was to evaluate the gene expression of the DNA mismatch repair gene MSH2 as a predictive marker in advanced colorectal cancer (CRC) treated with first-line capecitabine.

Patients and Methods:

Microdissection of paraffin-embedded tumor tissue, RNA extraction, and quantitative polymerase chain reaction were performed on tumors obtained from 37 patients with advanced CRC.


The median relative gene expression of MSH2 was 0.65 (quartiles 0.5–0.8) in nonresponders and 1.25 (quartiles 0.92–1.38) for responders (P = 0.038). High expression of MSH2 was associated with a hazard ratio of 0.5 (95% confidence interval, 0.23–1.11; P = 0.083) in survival analysis.


The higher gene expression of MSH2 in responders and the trend for predicting overall survival indicates a predictive value of this marker in the treatment of advanced CRC with capecitabine.

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