Association analysis of hepatitis virus B infection with haplotypes of the TBX21 gene promoter region in the Chinese population

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Abstract

Background

The T-box21 (TBX21) gene encodes the transcription factor T-bet (T-box expressed in T-cells), which influences naive T-lymphocyte development and has been implicated in the pathogenesis of many diseases.

Methods

We selected 208 hepatitis B patients and 213 healthy volunteers to examine whether polymorphisms or haplotypes of the TBX21 gene promoter were associated with hepatitis B virus (HBV) infection in the Chinese population. Two polymorphisms at −1499 and −1514 located in the TBX21 promoter region were identified by the PCR-restriction fragment length polymorphism (PCR-RFLP) method.

Results

Single nucleotide polymorphism (SNP) at −1499 was significantly different between HBV patients and healthy controls [p = 0.003; odds ratio (OR) 3.65, 95% confidence interval (CI) 1.58–8.45]. Similarly, our results showed a significantly higher level of haplotype D (–/AC) in HBV patients compared to control subjects (p = 0.005; OR 4.82, 95% CI 1.59–14.61).

Conclusions

Based on our findings, it seems that genetic variations of allele −1499 and haplotype D (–/AC) within the TBX21 promoter region contribute to susceptibility to HBV infection in the Chinese population.

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