5′ ins/del and 3′ VNTR polymorphisms in the apolipoprotein B gene in relation to lipids and coronary artery disease

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Abstract

Background

Studies that considered apolipoprotein B (APOB) gene polymorphisms as risk factors for coronary artery disease (CAD) have reported conflicting results. We sought to analyze the association between 5′ins/del and 3′VNTR polymorphisms of APOB, lipid parameters and CAD risk.

Methods

We recruited 251 patients with CAD, documented by coronary angiography, and 94 controls. Genotyping was performed by PCR. Lipids and apo-lipoproteins were measured.

Results

5′ins/del (ins/ins, ins/del, del/del) and 3′VNTR (LL, SS, LS) polymorphism frequencies were significantly (p<0.05) different between controls and CAD patients. LL and del/del were significantly associated with higher levels of apolipoprotein B (apoB), total cholesterol/high-density lipoprotein cholesterol ratio and apoB/apoA-I ratio (p<0.05) and with increased risk of CAD. The odds ratio for significant coronary stenosis associated with del/del was 3.2 (95% CI 1.6–36.42) (p = 0.032) and with LL was 2.2 (95% CI 1.1–5.1) (p = 0.042).

Conclusions

The two polymorphisms exert an impact on lipid levels and contribute to the susceptibility to the development of CAD.

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