Critically ill patients in the intensive care unit (ICU) who require mechanical ventilation often require continuous sedation infusions. These 2 interventions are associated with adverse outcomes such as increased duration of mechanical ventilation, increased length of stay in both the ICU and the hospital, and significant physiological and psychological complications. Daily sedation interruption (DSI) can reduce these adverse effects thereby improving long-term outcomes after critical illness. Conclusion: DSI is safe, practical, cost-effective, and results in positive outcomes for patients; however, there are barriers to implementing and incorporating DSI into daily practice. Further research is required to provide additional evidence and promote more widespread utilization.