Imaging of Tetralogy of Fallot: A Continuum From Infancy To Adulthood

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Abstract

Tetralogy of Fallot (TOF) is the most common form of cyanotic congenital heart disease. This disease accounts for approximately 10% of all congenital heart defects, affecting males and females equally.1 In addition, tetralogy of Fallot is the most common cyanotic heart disease that survives to adulthood. Although the cause for this disease is unknown, genetic mutations have been suggested to play a role: the occurrence rate from parent to child has been estimated to be as high as 8%. Mutations in a ligand expressed in the developing heart have been reported, as have transcription factor mutations and microdeletions on chromosome 22.1

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