Gadobutrol: A Review of Its Use for Contrast-Enhanced Magnetic Resonance Imaging in Adults and Children

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Abstract

Since the introduction of the first gadolinium-based contrast agent (GBCA) approximately 25 years ago, magnetic resonance imaging (MRI) using GBCAs has revolutionized diagnostic and follow-up imaging of pathological lesions, with clinical applications expanded to encompass almost all fields of medicine. Intravenous gadobutrol (GadovistTM [EU]; Gadavist® [USA]) is a second-generation extracellular non-ionic macrocyclic GBCA that is used in patients undergoing diagnostic contrast-enhanced MRI for visualization of pathological lesions in the CNS and all other body regions or for contrast-enhanced magnetic resonance angiography (MRA) to evaluate perfusion and flow-related abnormalities. Its unique physicochemical profile, along with the high thermostability of macrocyclic GBCAs, means gadobutrol is formulated at twice the gadolinium ion concentration of other currently licensed GBCAs. This reduces the injection volume and provides a narrower bolus, thereby improving image enhancement. Based on extensive clinical experience in a broad range of patients, including paediatric and adult patients (younger and elderly adults), and those with moderate to severe hepatic or renal impairment or cardiovascular disorders, gadobutrol is an effective and generally well tolerated extracellular GBCA for patients undergoing diagnostic contrast-enhanced MRI and contrast-enhanced MRA. As with all macrocyclic GBCAs, the potential for gadobutrol to cause nephrogenic systemic fibrosis appears to be lower than with linear GBCAs.

Gadobutrol for contrast-enhanced magnetic resonance imaging: a summary

Extracellular non-ionic macrocyclic gadolinium-based contrast agent (GBCA), with high thermostability and proton relaxation times

Gadobutrol for contrast-enhanced magnetic resonance imaging: a summary

Extensive clinical evidence confirms its diagnostic efficacy in adult, adolescent and paediatric patients as a GBCA in diagnostic contrast-enhanced magnetic resonance imaging of pathological lesions in the CNS and all other body regions

Gadobutrol for contrast-enhanced magnetic resonance imaging: a summary

Significant agreement in the diagnosis of flow-related abnormalities between gadobutrol-enhanced magnetic resonance angiography and intra-arterial digital subtraction angiography

Gadobutrol for contrast-enhanced magnetic resonance imaging: a summary

Generally well tolerated across a broad range of patients, with a lower potential than linear GBCAs to cause nephrogenic systemic fibrosis

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