Role of antiproliferative geneTob1in the immune system

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Abstract

Tob1 (transducer of ERBB2-1, TOB1 is human) is a member of the antiproliferative (APRO) family of proteins that controls cell cycle progression in several cell types. In addition, Tob1 has been implicated in diverse cellular mechanisms, such as embryonic dorsal development and T helper 17 (Th17) cell function. More recently, evidence linking Tob1 function to experimental and human immune-related disorders has mounted, thus underscoring the potential of this molecule as a biomarker and as a therapeutic target. The present article reviews these functions with an emphasis on their implications for human autoimmune diseases, such as multiple sclerosis.

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