Amyloid-β hypothesis in Alzheimer's disease and neurotoxicity of oligomeric amyloid through glial cells

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Amyloid hypothesis is considered to be the most feasible hypothesis for the pathogenesis of Alzheimer's disease (AD). Based on this hypothesis, various therapeutic approaches were examined for AD. In this issue, Horiuchi et al. showed oligomeric amyloid-β causes glia-mediated excitotoxicity in vitro, which might introduce another approach for the treatment of AD.

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