Predictors of Long-Term Response With Pazopanib in Patients With Advanced Renal-Cell Carcinoma

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Abstract

Micro-Abstract

Few reports of long-term response with pazopanib in advanced renal-cell carcinoma (aRCC) exist, and associated factors are unknown. A total of 153 first-line pazopanib-treated patients with aRCC were evaluated for long-term response (progression-free survival ≥ 18 months) in a real-world setting. An Eastern Cooperative Oncology Group performance status of 0 and nephrectomy history were significant predictors of long-term response in this patient population.

Background:

Pazopanib is among the current standards of care for first-line treatment of patients with unresectable advanced renal-cell carcinoma (aRCC) or metastatic renal-cell carcinoma. This real-world study aimed to characterize those with long-term response to pazopanib in the treatment of aRCC in a community oncology setting, and to identify predictors of long-term response.

Patients and Methods:

aRCC patients treated with first-line pazopanib were classified as having long-term or non–long-term response (progression-free survival [PFS] of ≥ 18 or < 18 months, respectively). Baseline patient demographics and clinical characteristics were evaluated and compared between the 2 groups. Differences in PFS and overall survival were also evaluated.

Results:

A total of 153 eligible patients were identified, of which 33 (21.6%) and 120 (78.4%) patients were identified as having disease with long-term and non–long-term response, respectively. The median PFS for those with long-term response was 27.2 months (95% confidence interval [CI], 23.0-35.2) versus 6.9 months (95% CI, 5.0-8.6) for those with non–long-term response. Median overall survival was not reached (NR) for those with long-term response (95% CI, NR to 39.1) compared to 15.3 months (95% CI, 12.3-21.6) for those with non–long-term response. Baseline Eastern Cooperative Oncology Group Performance Status (ECOG PS) of 0 (vs. ECOG PS of 1 and ≥ 2) and history of nephrectomy were identified as significant predictors of long-term response to pazopanib.

Conclusion:

In aRCC patients treated with first-line pazopanib, 22% had a long-term response. Significant predictors of long-term response included an ECOG PS of 0 and a history of nephrectomy.

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