Candida Rugosa LIPASE-CATALYZED KINETIC RESOLUTION OF 3-(ISOBUTYRYLOXY)METHYL 4-[2-(DIFLUOROMETHOXY)PHENYL]-2-METHYL-5,5-DIOXO-1,4-DIHYDROBENZOTHIENO[3,2-b]PYRIDINE-3-CARBOXYLATE

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Abstract

The lipase-catalyzed kinetic resolution of 3-(isobutyryloxy)methyl 4-[2-(difluoromethoxy)phenyl]-2-methyl-5,5-dioxo-1,4-dihydrobenzothieno[3,2-b]pyridine-3-carboxylate has been performed. The most enantioselective reaction (E = 28) was transesterification with n-butanol in water-saturated toluene at 45°C.

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