Respiratory Distress Due to Minocycline-Induced Pulmonary Lupus*

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Minocycline, a semisynthetic tetracycline, is often used to treat acne and rheumatoid arthritis.It has been considered an unlikely drug to be associated with systemic lupus erythematosus; however, many cases of drug-induced lupus related to minocycline have been reported. Some of those reports included pulmonary lupus, but none of the patients described developed respiratory distress. We describe a patient treated with minocycline for 2 years who presented with progressive dyspnea, severe hypoxia, and pulmonary infiltrates necessitating hospitalization and oxygen supplementation.

(CHEST 1999; 115:1471-1473)

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