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Social media sites such as Twitter can significantly enhance education and advocacy efforts. In 2013, the American College of Chest Physicians (CHEST) launched a Twitter chat series using the hashtag #pulmcc to educate and advocate for topics related to pulmonary, critical care, and sleep medicine.To assess the reach of these chats, we analyzed the metrics using Symplur analytics, and compared data from each chat, as well as participant data.Since December 19, 2013, there have been 12 Twitter chats: six have been on critical care-related topics, four have been on pulmonary-/sleep-related topics, and two have been conducted during the CHEST annual meeting on more general topics. During these 1-h Twitter chats, there were a total of 4,212 tweets by 418 participants, resulting in 9,361,519 impressions (ie, views). There were similar numbers of participants and tweets in the three categories of Twitter chats, but there was a significantly greater reach during the more general Twitter chats conducted at the CHEST annual meeting, with 1,596,013 ± 126,472 impressions per chat session at these chats, compared with 739,203 ± 73,109 impressions per chat session during the critical care Twitter chats and 621,965 ± 123,933 impressions per chat session in the pulmonary/sleep chats. Seventy-five participants participated in two or more #pulmcc Twitter chats, and the average percent of return participants in each chat was 30% ± 7%. Most of the return participants were health-care providers.Twitter chats can be a powerful tool for the widespread engagement of a medical audience.