Ventricular Aneurysms Complicating Coxsackievirus Group B, Types 1 and 4 Murine Myocarditis

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Abstract

SUMMARY

Suckling Swiss Webster mice were inoculated with 104TCD50 of coxsackieviruses, group B types 1 or 4. Virulent necrotizing myocarditis resulted in 185 infected mice. Of the latter group, three (14.3%) nurslings on the 17th and 23rd day after inoculations had left ventricular aneurysms postmortem. None of 61 concurrently matched control mice developed aneurysms. Ventricular aneurysm is a suggested but previously undocumented complication of murine, and possibly human necrotizing transmural coxsackievirus myocarditi

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