Examination of ECGs in patients with intermittent left bundle branch block (LBBB) may provide insight into mechanisms cause of LBBB. In this study, we obtained ECG files of patients with intermittent LBBB by mail solicitation of cardiologists. The group suitable for analysis included 275 patients in whom both LBBB was documented at least one 12-lead ECG was available which demonstrated absence of LBBB (ALBBB) after the first LBBB ECG. ALBBB ECGs revealed normalQRS in 151 patients (55%), abnormal QRS in 124 (45%). These 124 had one or more of the following: left ventricular hypertrophy 53 patients (19% of total group), myocardial infarction (MI) — 53 patients (19% of total group) conduction disturbance (QRS > 0.10 sec/or axis of −30° to −90°) — 52 patients (19% of total group). Sixty-three MIs were localized in the 53 patients; 31 (49%) were anteroseptal, seven (11%) were anterior, 17 (27%) were inferior eight (13%) were lateral (p ≤ 0.10). The 52 patients with conduction defects had the following: left anterior hemiblock-- 32 patients (62% of conduction defects, 12% of total group), incomplete LBBB 19 patients (31% of conduction defects, 7% of total group), right bundle branch block one patient (2% of conduction defect, 0.1% of total group).
More than 50% of the patients with intermittent LBBB did not have abnormal QRS, suggesting an underlying cause of LBBB. If underlying infarction is present, it is most commonly anteroseptal, implying disease of the left anterior descending coronary artery.
The site of most intermittent LBBB appears predivisional (His or main left bundle), since preexisting leftsided unifascicular block is infrequent.