Effects of Recombinant Apolipoprotein A-IMilano Aortic Atherosclerosis in Apolipoprotein E-Deficient Mice

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Abstract

Background

We previously reported marked inhibitory effects of recombinant apolipoprotein (apo) A-IMilano/phospholipid complex (A-IMilano/PC) on neointimal lesions in balloon-injured iliofemoral arteries of hypercholesterolemic rabbits. In this study, we tested the hypothesis that apo A-IMilano/PC would inhibit aortic atherosclerosis in apo E-deficient mice.

Conclusions

Recombinant A-IMilano/PC prevented progression of aortic atherosclerosis and reduced lipid and macrophage content of plaques in apo E-deficient mice despite severe hypercholesterolemia. Thus, A-IMilano/PC may have a role in inhibiting progression and promoting stabilization of atherosclerosis. (Circulation. 1998;97:780-785.)

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