Effects of Intranasal Administration of Recombinant Murine Interferon-gamma on Murine Acute Myocarditis Caused by Encephalomyocarditis Virus

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Viral myocarditis has been strongly implicated in the pathogenesis of dilated cardiomyopathy as well as acute myocarditis. Among the antiviral therapies, interferons (IFNs) have been widely studied and become very important in clinical practice.


Our data demonstrate that IFN therapy, especially intranasal administration of IFN-gamma, dramatically improved the prognosis of acute murine viral myocarditis by suppressing virus replication and raises the possibility of antiviral therapy with IFN-gamma in patients with acute myocarditis. (Circulation. 1998;97:1017-1023.)

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