Interaction of Coagulation Defects and Cardiovascular Risk Factors: Increased Risk of Myocardial Infarction Associated With Factor V Leiden or Prothrombin 20210A

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A genetic variation located in the 3 [prime]-untranslated region of the prothrombin gene (prothrombin 20210 G[right arrow]A) was recently described as a risk factor for venous thrombosis. We examined how the presence of this mutation affected the risk of myocardial infarction in a population-based case-control study. Furthermore, we studied the risk of myocardial infarction associated with the simultaneous presence of a coagulation defect (ie, the 20210 AG genotype of prothrombin or the factor V Leiden mutation) and major cardiovascular risk factors.


We conclude that in men the 20210 G[right arrow]A variant of prothrombin is associated with an increased risk of myocardial infarction. The combined presence of major cardiovascular risk factors and carriership of a coagulation defect increases the risk considerably. (Circulation. 1998;97:1037-1041.)

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