Expression of LDL Receptor, VLDL Receptor, LDL Receptor-Related Protein, and Scavenger Receptor in Rabbit Atherosclerotic Lesions: Marked Induction of Scavenger Receptor and VLDL Receptor Expression During Lesion Development

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Abstract

Background

Atherosclerotic lesions contain foam cells that arise from monocyte-macrophages and smooth muscle cells (SMCs) by excessive uptake of lipoproteins. There are many candidate receptors for the lipid accumulation, such as LDL receptor (LDLR), VLDL receptor (VLDLR), LDL receptor-related protein (LRP), and scavenger receptors (SRs). However, little quantitative information exists on the expression of these receptors in normal and atherosclerotic arteries.

Conclusions

SR and VLDLR mRNAs were highly induced in atherosclerotic lesions. VLDLR and LRP may be involved in the formation of both SMC-and macrophage-derived foam cells, whereas SRs play an important role in lipid uptake in macrophages. (Circulation. 1998;97:1079-1086.)

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