Left Ventricular Structure and Function in Children Infected With Human Immunodeficiency Virus: The Prospective P2 C2 HIV Multicenter Study

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The frequency of, course of, and factors associated with cardiovascular abnormalities in pediatric HIV are incompletely understood.


Subclinical cardiac abnormalities in HIV-infected children are common, persistent, and often progressive. Dilated cardiomyopathy (depressed contractility and dilatation) and inappropriate LV hypertrophy (elevated LV mass in the setting of decreased height and weight) were noted. Depressed LV function correlated with immune dysfunction at baseline but not longitudinally, suggesting that the CD4 cell count may not be a useful surrogate marker of HIV-associated LV dysfunction. However, the development of encephalopathy may signal a decline in FS. (Circulation. 1998;97:1246-1256.)

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